To assist metacell object building in determining the metacell covariates (metadata)
mcRigor_covariate.RdTo assist metacell object building in determining the metacell covariates (metadata)
Usage
mcRigor_covariate(
sc_covariate,
sc_membership,
method = c("jaccard", "relative", "absolute")
)Arguments
- sc_covariate
a vector (or dataframe) of single cell covariates
- sc_membership
a vector (or dataframe) of metacell memberships of single cells
- method
method to define the most abundant cell covariate within metacells. Available: "jaccard" (default), "relative", "absolute".
jaccard - assign metacell to covariate with the maximum jaccard coefficient (recommended)
relative - assign metacell to covariate with the maximum relative abundance (normalized by cluster size), may result in assignment of metacells to poorly represented (small) covariate due to normalization
absolute - assign metacell to covariate with the maximum absolute abundance within metacell, may result in disappearance of poorly represented (small) clusters